3'-Aminoadenosine-5'-uronamides: discovery of the first highly selective agonist at the human adenosine A3 receptor

Michael P DeNinno; Hiroko Masamune; Lois K Chenard; Kenneth J DiRico; Cynthia Eller; John B Etienne; Jeanene E Tickner; Scott P Kennedy; Delvin R Knight; Jimmy Kong; Joseph J Oleynek; W Ross Tracey; Roger J Hill

doi:10.1021/jm0255724

3'-Aminoadenosine-5'-uronamides: discovery of the first highly selective agonist at the human adenosine A3 receptor

J Med Chem. 2003 Jan 30;46(3):353-5. doi: 10.1021/jm0255724.

Authors

Michael P DeNinno¹, Hiroko Masamune, Lois K Chenard, Kenneth J DiRico, Cynthia Eller, John B Etienne, Jeanene E Tickner, Scott P Kennedy, Delvin R Knight, Jimmy Kong, Joseph J Oleynek, W Ross Tracey, Roger J Hill

Affiliation

¹ PGRD Groton Laboratories, Pfizer Inc., Groton, Connecticut 06340, USA. michael_p_deninno@groton.pfizer.com

PMID: 12540233
DOI: 10.1021/jm0255724

Abstract

Selective adenosine A(3) agonists have potential utility for the prevention of perioperative myocardial ischemic injury. Herein, we report on the discovery and synthesis of compound 7. This amino nucleoside agonist possesses unprecedented levels of selectivity for the human adenosine A(3) receptor.

MeSH terms

Adenosine / analogs & derivatives*
Adenosine / chemical synthesis*
Adenosine / chemistry
Adenosine / pharmacology
Amides / chemical synthesis
Amides / chemistry
Amides / pharmacology
Cell Line
Humans
Isoxazoles / chemical synthesis*
Isoxazoles / chemistry
Isoxazoles / pharmacology
Purinergic P1 Receptor Agonists*
Receptor, Adenosine A3
Structure-Activity Relationship

Substances

Amides
CP 608039
Isoxazoles
Purinergic P1 Receptor Agonists
Receptor, Adenosine A3
Adenosine